The Era of Precision Medicine
Precison medicine is an emerging approach for disease treatment and prevention, and considers individual variability in environment, lifestyle, and genes for each person. Genomix University specializes in providing references on clinical genetic testing in the areas of pharmacogenetics, haptoglobin genotyping, and advanced cardiology genetics.
What Is Pharmacogenetic Testing?
Pharmacogenetics is the study of how genes affect a person’s response to drugs. This relatively new field combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop effective, safe medications and doses that are tailored to a person’s genetic makeup.
Many drugs that are currently available are prescribed as a one dose suits all patients. In reality, drugs do not work the same way for everyone. Often clinicians can have difficulty in predicting who will benefit from a medication, who will not respond at all, and who will experience negative side effects (called adverse drug reactions).
Certain genes affect the metabolism of hundreds of clinically significant drugs. You can now determine the right drug, the correct dose, the first time. This is especially important for those on antiplatelets, anticoagulants, beta blockers, pain, and behavioral health medication, as well as black box and expensive specialty drugs.
Adverse drug reactions are a significant cause of hospitalization and death in the United States. The knowledge obtained from the Human Genome Project and the latest advances in cost effective sequencing has brought researchers and clinicians to the leading edge in precision drug therapy. Researchers are learning how inherited differences in genes affect the body’s response to medications. These genetic differences are used to predict whether a given medication will be effective for a particular person and to prevent adverse drug reactions.
The decision about which drug to prescribe may also be influenced by other drugs that the patient is taking. Pharmacogenetics can not only provide precision guidance on the best therapy for a given patient but can also inform on how to best avoid drug-drug interactions.
What is Haptoglobin Genotyping?
36% of people with diabetes carry at least one copy of a high risk genetic variant that greatly increases the likelihood of having a heart attack or stroke. Haptoglobin genotyping identifies those at high risk. High risk patients can reverse the additional risk with tailored dosing of a vitamin supplement.
MyHap2™ is a proprietary genetic test that identifies increased cardiovascular risk in patients with diabetes. Over half of the diabetic population dies of cardiovascular disease. If a patient with diabetes carries one or more of the haptoglobin-2 variants, their increased risk of a heart attack or stroke skyrockets 500% higher. Vitamin therapy can be tailored to reduce the risk back to baseline for patients that carry two copies.
Why Advanced Cardiology Genetics?
There are several advanced genetic tests and Next Generation Sequencing to aid in diagnosis, prognosis, and treatment of many cardiac conditions.
MyGenetx offers Next Generation Sequencing (NGS) testing to aid in diagnosis, prognosis, and treatment of many disorders, such as:
• Familial Hypercholesterolemia • Brugada • Short QT
• Long QT • CPVT • Cardiomyopathy
• Noonan’s • Aortic Disease